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As there are different types of WBCs, as their functions vary, their disorders also vary.


  • Neutrophils – neutrophilia – increase in its count; neutropenia – decrease in its count.
  • Eosinophil – eosinophilia – increase in its count; eosinopenia – decrease in its count.
  • Basophils – basophilia – increase in the number of basophils.


  • Lymphocytes – lymphocytosis – increase in the count of lymphocytes; lymphopenia – an absolute decrease in the count of lymphocytes.
  • Monocytes – monocytosis – it is the rise in the blood monocytes.
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Following are the disorders which causes high white blood cell count:

  1. High abnormal production of white blood cell due to disease of bone marrow.
  2. Increased white blood cell count due to disorder related to immune system.
  3. Increase in white blood cell count due to reaction to a drug.
  4. There increased production of white blood cell during an infection to fight against it.

Following are the specific cause of the high white blood cell count:

  1. An allergic reaction
  2. Chronic lymphocytic leukemia
  3. Medicinal drugs like epinephrine and corticosteroids
  4. Chronic myelogenous leukemia
  5. Acute myelogenous leukemia
  6. Acute lymphocytic leukemia

Following are the disorders which cause low White Blood Cell Count:

  1. The temporary Bone Marrow destruction due to the viral infection.
  2. The diminished bone marrow due to any congenital disorders.
  3. The Bone marrow damage due to any chronic degenerative diseases like cancer.
  4. The white blood cell destruction or the destruction of the bone marrow cells due to an autoimmune disorder.
  5. The chronic illness due to which the white blood cells of the body are used up in faster rate then their production.
  6. The destruction of the white blood cells or destruction of bone marrow cells due to drugs.

Following are specific causes of low white blood cell count:

  1. Infectious diseases
  2. Due to some medications like diuretics and antibiotics
  3. Aplastic anemia
  5. Chemotherapy
  6. Leukemia
  7. Myelodysplastic syndromes
  8. Malnutrition
  9. Lupus
  10. Kostmann’s syndrome (congenital disorder where there is low neutrophil count due to low its production).
  11. Hypersplenism, a premature destruction of blood cells by the spleen.
  12. Parasitic diseases
  13. Radiation diseases
  14. Myelokathexis (congenital disorder where there is failure of neutrophils to enter the bloodstream).
  15. Any Autoimmune disorders.
  16. Any Congenital disorders.
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