Prothrombin is the most important clotting factor in coagulation of blood. The coagulation of blood takes place in following ways-
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Prothrombin is chemically in active which is converted or made active moiety as thrombin
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The enzyme or factor associated with conversion is prothrombinase or factor x
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Now thrombin gets converted to fibrinogen which when comes in contact with platelets present in blood results in clot formation.