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Genomic DNA
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Plasmid DNA
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1. Genomic DNA is chromosomal DNA where the genetic material is present.
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1. Plasmid DNA is extra-chromosomal DNA in bacteria and some yeasts, i.e. Plasmid.
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2. It is primary DNA in all living organisms.
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2. It is secondary DNA.
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3. It is linear in eukaryotes whereas circular in prokaryotes.
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3. It is circular.
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4. As it encodes genetic information, it is much larger than plasmid.
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4. It is smaller.
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5. Genomic DNA is organized with proteins called histones.
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5. Plasmid DNA is not with histones.
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6. It contains essential genes which codes for functional and structural proteins.
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6. It contains non-essential genes.
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7. It can be transferred only through cell division within the same species.
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7. It can be transferred through horizontal way of gene transfer between same or different species.
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8. Genomic DNA cannot be used in recombinant DNA technology.
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8. Plasmid DNA are used extensively in recombinant DNA technology.
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9. In a normal cell only one copy of genomic DNA is present.
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9. There can be multiple, identical copies of plasmids present in cell.
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